Jan 2, - Has anybody used tramadol for depression? I started taking it for back pain and found that it made me feel "normal" again. I am able to relax. Jul 23, - Tramadol (Ultram) is prescribed for treating moderate to severe pain in adults. You may be at greater risk for respiratory depression if you use. Jul 31, - shared monoaminergic action resulted in the research of tramadol as a potential treatment for depression. The. present article intends to.